Possible New Narcolepsy Treatment Found
A new possible better treatment for narcolepsy has been identified by neuroscientists at SRI international. A drug known as Baclofen, which is generally used treating muscle spasticity has shown better results in treating narcolepsy, when tested on mice.
Narcolepsy is one of the most commonly found sleep disorder, which is characterized by excessive daytime sleepiness. It is estimated that 1 out of every 2000 people in world is a patient of narcolepsy.
A new mouse model of narcolepsy was presented by Thomas Kilduff, Ph.D., who directs the Center for Neuroscience and Sarah Wurts Black, Ph.D, a research scientist from Center for Neuroscience presented. This model mimics narcolepsy in humans better than standard existing model known as Ataxin mice.
Dr. Kilduff said that this provides a chance for identifying a new and better narcolepsy treatment. According to the researchers, R-baclofen, which is a form of baclofen has shown better results than the presently existing FDA approved narcolepsy treatments.
Baclofen is available in the market from longtime, and it is available in the two forms namely R and S. Dr. Kilduff also said that their next step is to study how well this medicines works in treating human narcoleptic patients.
R-baclofen promoted sleep time and longer periods of wakefulness in the mice during appropriate times. Presently available narcolepsy medicine GHB worked modestly in improving sleep intensity, and in reduces cataplexy. But, when it comes to other narcolepsy symptoms R-baclofen worked far better than GHB.
Generally, the onset of narcolepsy starts in the age of adolescents or above. But, it may even take a decade to get diagnosed. As a result, it make difficult to study about narcolepsy prognosis.
As the exact cause for why brain awry its ability to regulate circadian rhythms is still unknown, presently there are narcoleptic medicines that address the symptoms rather than curing the underlying causes of narcolepsy.